Toxicity of Nanomaterials to Living Cells
نویسندگان
چکیده
We have studied the toxicity of luminescent silica nanoparticles to living cells from the whole cell level to the molecular level, such as the effects of the nanoparticles on DNA/protein damage, DNA repair activity, cell apoptosis, cell proliferation and death. Several biological approaches were employed to characterize the toxicity of the nanoparticles, including Vybrant apoptosis assay, MTT assay, DNA repair enzyme activity assay and comet assay. Preliminary results showed that the nanoparticles have no apparent effects on survival in several types of living cells up to 72 hours of incubation. Furthermore, luminescent silica nanoparticles do not cause significant DNA damage (strand breaks) compared to controls.
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تاریخ انتشار 2005